The market competition in the livestock industry is becoming increasingly fierce, and "antibiotic bans in feed" are becoming increasingly prominent. In order to ensure the quality of animal products and public biosafety, the Chinese Veterinary Pharmacopoeia Committee recommends stopping the use of ampicillin, roxarsone, olaquinedox, etc. The Ministry of Agriculture issued a notice prohibiting the addition of colistin sulfate to feed and clarified that antibiotics cannot be used as feed additives and can be used as therapeutic drugs after animals show symptoms. The widespread application of new technologies such as high-throughput screening has greatly improved the efficiency of new drug development. However, about 90% of new drugs developed are poorly water-soluble drugs. Because the dissolution rate of poorly soluble drugs in the gastrointestinal tract is slow, their absorption is limited and their bioavailability is low. The nanoparticles obtained by further crushing the micronized drug into nanosuspensions can simultaneously improve the solubility and dissolution rate of the drug.
Micronized drugs are prepared into a suspension, which passes through the slit of the homogenization valve at high speed under the action of high-pressure homogenization. The drug suspension that loses instantaneous pressure is ejected at a very high flow rate and collides with the impact ring, with the cavitation effect, impact effect and shearing effect, then the nanosuspensions are produced.